Pre-disease
The biology that will either permit or resist future disease expression.
The biology that will either permit or resist future disease is already being shaped, long before any diagnosis arrives.
2 papers. Why they matter here.
- Paper 1
Mutations Provide Potential, but Environment Determines Expression
Read the paper →Establishes why the biological terrain, not genetics alone, determines whether latent cancer ever becomes clinical disease.
- Paper 2
Metabolism, Epigenetics, and Lineage Plasticity
Read the paper →Identifies how metabolic conditions shape cellular identity and constrain or permit future disease expression.
11 papers. Why they matter here.
- Paper 1
The Primer
Read the paper →The full technical foundation. What prostate cancer actually is biologically, and why containment is the default state.
- Paper 2
Chronic Activation vs Oscillation
Read the paper →Why the loss of metabolic rhythm, not any single pathway, is the precise upstream condition that permits disease expression.
- Paper 3
mTOR as Integrative Hub
Read the paper →How chronic mTOR activation corrupts cellular intelligence and creates the metabolic conditions for disease permissiveness.
- Paper 4
MDM2 as Convergence Point
Read the paper →The single upstream event, AKT -> MDM2, that simultaneously suppresses quality control and dysregulates androgen signalling.
- Paper 5
Mitophagy and Mitochondrial Quality Control
Read the paper →Why mitochondrial quality is the cellular foundation of the structural layer, and what its decline means for containment.
- Paper 6
Retatrutide as Metabolic Field Maintenance
Read the paper →Restoring the systemic metabolic baseline on which all other terrain interventions depend.
- Paper 7
Pioglitazone at Low Dose
Read the paper →Slow structural remodelling of the metabolic and stromal environment. The most upstream pharmacological intervention.
- Paper 8
Oestrogen's Role in Prostate Cancer
Read the paper →The four oestrogen mechanisms that shape terrain: receptor balance, intratumoral aromatase, estrobolome, xenoestrogens.
- Paper 9
Testosterone, p53, and the MDM2 System
Read the paper →Why physiological testosterone preserves the androgen receptor's normal behaviour, and why hypogonadism is a permissive terrain condition.
- Paper 10
Sirtuins, NAD⁺, and the Quiet Biology Framework
Read the paper →The AMPK-NAD⁺-SIRT1 axis as a second parallel control layer operating on the same upstream terrain.
- Paper 11
A Hierarchy of Biological Signals
Read the paper →The architectural frame. Phase 1 terrain conditions are Level 1 field disruption, the earliest and most modifiable signals in the hierarchy.