Twenty-three papers, two collections , one coherent argument .
5 foundational papers supporting the white paper. 18 framework papers developing the QB mechanistic series. Every reference anywhere on the site points back to this archive.
- 01Read the paper →
Mutations Provide Potential, but Environment Determines Expression
Autopsy pathology. The foundational paradox establishing why terrain matters.
- 02Read the paper →
Metabolism, Epigenetics, and Lineage Plasticity
How metabolic state governs cellular identity and evolutionary trajectory.
- 03Read the paper →
Tumour Ecology and Evolutionary Stability
The ecological model of tumour progression. Why stability is actively maintained, and what its collapse enables.
- 04Read the paper →
Cancer as an Ecological and Evolutionary System
The capstone paper. Gatenby, Aktipis, and Zhang on why ecological management outperforms elimination, with clinical trial validation.
- 05Read the paper →
PSA Kinetics and the Natural History of Prostate Cancer
Decades of natural history data, Johansson, Albertsen, PIVOT, ProtecT, establishing that biological constraint is the default state of most localised prostate cancer.
- 01Read the paper →
The Primer
Full technical paper. Containment, evolution, and the ecology of indolent prostate cancer.
- 02Read the paper →
Chronic Activation vs Oscillation
Why pulsatile and chronic signalling produce different cellular outcomes.
- 03Read the paper →
mTOR as Integrative Hub
mTOR as multi-signal integrator. Why rhythm loss is the precise mechanism of harm.
- 04Read the paper →
MDM2 as Convergence Point
One upstream cause, two converging failures. The central mechanistic argument.
- 05Read the paper →
Rapamycin, mTOR Oscillation, and the p53-MDM2 Axis
Full mechanism linking mTOR suppression to p53 functional restoration.
- 06Read the paper →
Testosterone, p53, and the MDM2 System
The saturation model. Why physiological TRT differs from supraphysiological exposure.
- 07Read the paper →
Sirtuins, NAD⁺, and the Quiet Biology Framework
Acetylation as a second parallel control layer alongside phosphorylation.
- 08Read the paper →
The Three Layers of Intervention
Output, signalling, and structural layers. Why durability requires acting across all three.
- 09Read the paper →
Signal, Stress, and Selection
The four-signal temporal architecture. Why sequencing matters more than activation strength.
- 10Read the paper →
Dynamic Fitness Landscapes and Evolutionary Constraint in Prostate Cancer
Why oscillating environments prevent tumour populations from reaching stable adaptive optima. The evolutionary mechanism underlying the protocol's design.
- 11Read the paper →
From Intervention to Environment
The protocol's operational logic. Signal clarity as the central design principle.
- 12Read the paper →
Mitophagy and Mitochondrial Quality Control
The PINK1/Parkin pathway. Why mitochondrial quality is the cellular foundation of the structural layer.
- 13Read the paper →
Retatrutide as Metabolic Field Maintenance
Triple agonism. Systemic metabolic field restoration as structural foundation.
- 14Read the paper →
Pioglitazone at Low Dose
PPAR-γ activation. Cumulative stromal remodelling at 7.5mg.
- 15Read the paper →
Doxycycline: Multi-Pillar Analysis
Full four-pillar convergence: MMP, CSC mitochondria, NF-κB -> p53, intraprostatic microbiome.
- 16Read the paper →
Oestrogen's Role in Prostate Cancer
Four-mechanism analysis. ERα/ERβ balance, intratumoral aromatase, estrobolome, xenoestrogens.
- 17Read the paper →
Bipolar Androgen Therapy: Clinical Validation
BAT mechanism. Oscillation principle applied to CRPC. PSA50 77-94%.
- 18Read the paper →
A Hierarchy of Biological Signals
Five levels from field conditions to clinical outcome. The architectural frame for the whole series.
Twenty-three papers. One download.
All foundational and framework papers, supplementary materials, and citation files.